ANTI-THYMOCYTE GLOBULIN INDUCED THROMBOCYTOPENIA

被引：0
|
作者：
LAZARCHICK, J
RUSSELL, R
HORN, B
机构：
来源：
ANNALS OF CLINICAL AND LABORATORY SCIENCE | 1990年 / 20卷 / 06期
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暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Anti-thymocyte globulin is strongly reactive with platelets as measured by flow cytometric analysis. This reactivity appears to be independent of human leukocyte antigen (HLA) phenotype, is dose-dependent with saturation of platelet binding sites readily achieved with concentrations of horse anti-thymocyte globulin (ATG) at 0.25 mg per ml, and cannot be blocked with human anti-PL(A1) antibody nor with heat-aggregated human IgG. Results of immunoblot studies after electrophoresis of platelet membrane proteins are consistent with the proposal that horse ATG contains antibodies specific for platelet glycoproteins V and IIa.
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页码：373 / 378
页数：6
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