THE IN-VITRO EFFECT OF MONENSIN ON BK POLYOMAVIRUS REPLICATION

被引：0
|
作者：
PIETROPAOLO, V
DEGENER, AM
DITARANTO, C
SINIBALDI, L
ORSI, N
机构：
来源：
MICROBIOLOGICA | 1995年 / 18卷 / 04期
关键词：
BK VIRUS; MONENSIN; T ANTIGEN; MOLECULAR HYBRIDIZATION;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro effect of monensin, a linear polyether, on the infection of Vero cells by BK polyomavirus, was investigated. Data reported in this paper showed an inhibition of BK viral replication by monensin as monitored by immunofluorescence and molecular hybridization. The inhibition of the synthesis of viral nuclear T antigen and the lack of production of viral mRNAs in monensin-treated cells suggest that the effect of this ionophore takes place at the level of the viral DNA delivery, by blocking the uncoating of BK virus or its transport to the nucleus.
引用
收藏
页码：341 / 349
页数：9
相关论文
共 50 条
  • [31] Time-dependent effect of cidofovir and leflunomide on polyomavirus BK replication and kidney cell viability.
    Rinaldo, Christine H.
    Bernhoff, Eva
    Tylden, Garth
    Sandvik, Kjersti
    Hirsch, Hans H.
    Gutteberg, Tore J.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 : 462 - 463
  • [32] A rapid in vitro polyomavirus DNA replication assay
    Ziegler, K
    Bui, T
    Frisque, RJ
    Grandinetti, A
    Nerurkar, VR
    JOURNAL OF VIROLOGICAL METHODS, 2004, 122 (01) : 123 - 127
  • [33] DNA REPLICATION IN-VITRO
    CAMPBELL, JL
    FLEISCHM.RA
    RICHARDS.CC
    FEDERATION PROCEEDINGS, 1971, 30 (03) : 1313 - &
  • [34] INHIBITORY EFFECT OF PYRIDOBENZAZOLES ON VIRUS-REPLICATION IN-VITRO
    CHIBA, T
    SHIGETA, S
    NUMAZAKI, Y
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1995, 18 (08) : 1081 - 1083
  • [35] Tumor necrosis factor-alpha blockade suppresses BK polyomavirus replication
    Li, Yi-Jung
    Wang, Jiun-Wen
    Wu, Hsin-Hsu
    Wang, Hsu-Han
    Chiang, Yang-Jen
    Yang, Huang-Yu
    Hsu, Hsiang-Hao
    Yang, Chih-Wei
    Tian, Ya-Chung
    INFECTION, 2023, 51 (04) : 967 - 980
  • [36] Tumor necrosis factor-alpha blockade suppresses BK polyomavirus replication
    Yi-Jung Li
    Jiun-Wen Wang
    Hsin-Hsu Wu
    Hsu-Han Wang
    Yang-Jen Chiang
    Huang-Yu Yang
    Hsiang-Hao Hsu
    Chih-Wei Yang
    Ya-Chung Tian
    Infection, 2023, 51 : 967 - 980
  • [37] Polyomavirus BK (BKV) Replication in Human Urothelial Cells Role in Polyomavirus-Associated Nephropathy and Hemorrhagic Cystitis
    Rinaldo, C. H.
    Li, R.
    Sharma, B. N.
    Linder, S.
    Gutteberg, T. J.
    Hirsch, H. H.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 : 348 - 348
  • [38] The ionophore monensin inhibits mouse polyomavirus DNA replication and destabilizes viral early mRNAs
    Iacoangeli, A
    Melucci-Vigo, G
    Risuleo, G
    BIOCHIMIE, 2000, 82 (01) : 35 - 39
  • [39] The Status of BK Polyomavirus Replication in Adult Renal Transplant Recipients in Northeastern Poland
    Naumnik, B.
    Kowalewska, J.
    Zalewski, G.
    Charkiewicz, R.
    Mysliwiec, M.
    TRANSPLANTATION PROCEEDINGS, 2011, 43 (08) : 2976 - 2984
  • [40] Prevalence of Polyomavirus BK and JC Infection and Replication in 400 Healthy Blood Donors
    Egli, Adrian
    Infanti, Laura
    Dumoulin, Alexis
    Buser, Andreas
    Samaridis, Jacqueline
    Stebler, Christine
    Gosert, Rainer
    Hirsch, Hans H.
    JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (06): : 837 - 846
12345