INTERLEUKIN-4 INDUCES ENDOTHELIAL VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) BY AN NF-KAPPA-B-INDEPENDENT MECHANISM

被引：31

作者：

MCCARTY, JM ^{[1
]}

YEE, EK ^{[1
]}

DEISHER, TA ^{[1
]}

HARLAN, JM ^{[1
]}

KAUSHANSKY, K ^{[1
]}

机构：

[1] REPLIGEN CORP,CAMBRIDGE,MA 02118

来源：

FEBS LETTERS | 1995年 / 372卷 / 2-3期

关键词：

VCAM-1; IL-4; ENDOTHELIAL CELL; GENE REGULATION;

D O I：

10.1016/0014-5793(95)00976-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While all features of the inflammatory response induced by IL-1 are not observed following IL-4 stimulation, suboptimal concentrations both cytokines result in synergistic VCAM-1 expression in HUVEC. We have shown that, while IL-1 stimulated HUVEC express GM-CSF, tissue factor and VCAM-1, only VCAM-1 is detectable after exposure to IL-4. While kB was found essential for both basal and IL-1-mediated activity of VCAM-1, IL-4 induction was kB-independent. Inducible kB-binding proteins were identified in IL-1-, but not IL-4-stimulated nuclear extracts. Our results indicate that IL-4 exerts its transcriptional effects on the VCAM-1 gene through element(s) which do not require kB.

引用

页码：194 / 198

页数：5

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