INTERLEUKIN-4 INDUCES ENDOTHELIAL VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) BY AN NF-KAPPA-B-INDEPENDENT MECHANISM

被引：31
|
作者：
MCCARTY, JM [1 ]
YEE, EK [1 ]
DEISHER, TA [1 ]
HARLAN, JM [1 ]
KAUSHANSKY, K [1 ]
机构：
[1] REPLIGEN CORP,CAMBRIDGE,MA 02118
来源：
FEBS LETTERS | 1995年 / 372卷 / 2-3期
关键词：
VCAM-1; IL-4; ENDOTHELIAL CELL; GENE REGULATION;
D O I：
10.1016/0014-5793(95)00976-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
While all features of the inflammatory response induced by IL-1 are not observed following IL-4 stimulation, suboptimal concentrations both cytokines result in synergistic VCAM-1 expression in HUVEC. We have shown that, while IL-1 stimulated HUVEC express GM-CSF, tissue factor and VCAM-1, only VCAM-1 is detectable after exposure to IL-4. While kB was found essential for both basal and IL-1-mediated activity of VCAM-1, IL-4 induction was kB-independent. Inducible kB-binding proteins were identified in IL-1-, but not IL-4-stimulated nuclear extracts. Our results indicate that IL-4 exerts its transcriptional effects on the VCAM-1 gene through element(s) which do not require kB.
引用
收藏
页码：194 / 198
页数：5
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