INHIBITORY EFFECTS OF QUASSINOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION

被引：27

作者：

OKANO, M

FUKAMIYA, N

TAGAHARA, K

TOKUDA, H

IWASHIMA, A

NISHINO, H

LEE, KH

机构：

[1] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE 665,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

[3] NATL INST CANC RES,DIV CANC PREVENT,TOKYO 103,JAPAN

[4] UNIV N CAROLINA,SCH MED,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

CANCER LETTERS | 1995年 / 94卷 / 02期

关键词：

ANTITUMOR PROMOTING EFFECT; EPSTEIN-BARR VIRUS ACTIVATION TEST; QUASSINOIDS; STRUCTURE-ACTIVITY RELATIONSHIPS;

D O I：

10.1016/0304-3835(95)03839-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.

引用

页码：139 / 146

页数：8

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