CHANGES OF OVARIAN HORMONAL FUNCTION WITH AGING

被引：49
|
作者：
JUDD, HL
FOURNET, N
机构：
[1] UNIV CALIF LOS ANGELES, DEPT OBSTET & GYNECOL, LOS ANGELES, CA 90024 USA
[2] CEDARS SINAI MED CTR, LOS ANGELES, CA 90048 USA
来源：
EXPERIMENTAL GERONTOLOGY | 1994年 / 29卷 / 3-4期
关键词：
TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; ESTRONE; WOMEN; POSTMENOPAUSE;
D O I：
10.1016/0531-5565(94)90008-6
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Striking changes of ovarian function occur with aging. These changes begin subtly with reductions of fecundability being observed after age 25. The transition from reproductive to postreproductive life is characterized by menstrual irregularity including anovulation, or short luteal phases. The most prominent hormonal changes at the menopause are drastic reductions of estradiol and progesterone secretion by the ovary, reflecting the cessation of folliculogenesis and ovulation. Elevations of gonadotropins and reduction of inhibin levels also reflect the loss of folliculogenesis and ovulation. There are accompanying decreases of ovarian androgen secretion; however, the postmenopausal gonad directly secretes more testosterone after, than before, the menopause.
引用
收藏
页码：285 / 298
页数：14
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