THE INTERACTION OF 5-FLUOROURACIL, HYDROXYUREA, AND RADIATION IN 2 HUMAN HEAD AND NECK-CANCER CELL-LINES

被引：0

作者：

VOKES, EE ^{[1
]}

BECKETT, M ^{[1
]}

KARRISON, T ^{[1
]}

WEICHSELBAUM, RR ^{[1
]}

机构：

[1] UNIV CHICAGO, MED CTR, DEPT RADIAT & CELLULAR ONCOL, CHICAGO, IL 60637 USA

来源：

ONCOLOGY | 1992年 / 49卷 / 06期

关键词：

5-FLUOROURACIL; HYDROXYUREA; RADIATION; HEAD NECK CANCER CELL LINES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the effects of 5-fluorouracil (5-FU) and hydroxyurea (HU) with radiation on two human head and neck squamous carcinoma cell lines. SQ-20B has a D0 of 239 cGy and an S phase fraction of 37%, while SQ-38 has a D0 of 146 cGy and an S phase fraction of 31%. For SQ-20B the surviving fraction at 100 cGy was significantly reduced (p < 0.05) when cells were exposed to HU or to 5-FU or both chemotherapy agents together with radiation. No significant effect was seen for SQ-38 with either chemotherapy agent alone or in combination with radiation as compared with radiation alone. Therefore, additive cytotoxicity between 5-FU and HU and radiotherapy was observed only in a head and neck cancer cell line with a higher DO and a higher S phase fraction.

引用

页码：454 / 460

页数：7

共 50 条

[41] Carboplatin and 5-fluorouracil in squamous cell carcinoma of the head and neck previously responding to cisplatin and 5-fluorouracil
Benasso, M
Numico, G
Merlano, M
EUROPEAN JOURNAL OF CANCER, 1997, 33 (02) : 318 - 319
[42] Enhanced radiation killing by 5-fluorouracil of biliary tract cancer cell lines
Moon, Y
Todoroki, T
Ohno, T
Fukao, K
Little, JB
INTERNATIONAL JOURNAL OF ONCOLOGY, 2000, 16 (05) : 987 - 994
[43] RESPONSE RATES AND SURVIVAL IN PATIENTS WITH HEAD AND NECK-CANCER TREATED WITH A COMBINATION OF CISPLATIN AND 5-FLUOROURACIL PRIOR TO RADIOTHERAPY
THOMAS, GD
PATERSON, ICM
CLINICAL RADIOLOGY, 1988, 39 (05) : 551 - 554
[44] INDUCTION CHEMOTHERAPY WITH CISPLATIN AND CONTINUOUS INFUSION 5-FLUOROURACIL IN LOCALLY FAR-ADVANCED HEAD AND NECK-CANCER
VERWEIJ, J
DEJONG, PC
DEMULDER, PHM
VANDERBROEK, P
ALEXIEVAFIGUSCH, J
VANPUTTEN, WLJ
SCHORNAGEL, JH
RAVASZ, LA
SNOW, GB
VERMORKEN, JB
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1989, 12 (05): : 420 - 424
[45] Phase II trial of concurrent 5-fluorouracil, hydroxyurea, cetuximab, and intensity moduled radiation therapy (IMRT) for locally advanced head and neck cancer
Kao, J.
Policarpio, L.
Teng, M.
Burri, R.
Genden, E.
Packer, S.
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
[46] DOSE REDUCTION WITHOUT LOSS OF EFFICACY FOR 5-FLUOROURACIL AND CISPLATIN COMBINED WITH FOLINIC ACID - INVITRO STUDY ON HUMAN HEAD AND NECK-CARCINOMA CELL-LINES
ETIENNE, MC
BERNARD, S
FISCHEL, JL
FORMENTO, P
GIOANNI, J
SANTINI, J
DEMARD, F
SCHNEIDER, M
MILANO, G
BRITISH JOURNAL OF CANCER, 1991, 63 (03) : 372 - 377
[47] EPIDERMAL GROWTH-FACTOR RECEPTOR GENE AMPLIFICATION AND EXPRESSION IN HEAD AND NECK-CANCER CELL-LINES
WEICHSELBAUM, RR
DUNPHY, EJ
BECKETT, MA
TYBOR, AG
MORAN, WJ
GOLDMAN, ME
VOKES, EE
PANJE, WR
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 1989, 11 (05): : 437 - 442
[48] P53 MUTATION DOES NOT CORRELATE WITH RADIOSENSITIVITY IN 24 HEAD AND NECK-CANCER CELL-LINES
BRACHMAN, DG
BECKETT, M
GRAVES, D
HARAF, D
VOKES, E
WEICHSELBAUM, RR
CANCER RESEARCH, 1993, 53 (16) : 3667 - 3669
[49] SEQUENTIAL CISPLATIN (DDP) AND 5-FLUOROURACIL (FU) IN ADVANCED SQUAMOUS-CELL HEAD AND NECK-CANCER (H-AND-N CA)
SRIDHAR, KS
HIRSCH, R
FOUNTZILAS, G
GOODWIN, WJ
ROBINSON, D
BRODER, LE
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 180 - 180
[50] ADVANCED HEAD AND NECK-CANCER - LOW-DOSE, SPLIT-COURSE RADIATION-THERAPY AND SIMULTANEOUS INFUSION OF 5-FLUOROURACIL AND CISPLATIN
STRYKER, JA
HARVEY, HA
HOUCK, JR
MANDERS, EK
BRADFIELD, JJ
RADIOLOGY, 1990, 176 (02) : 567 - 571

← 1 2 3 4 5 →