SYNTHESIS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4(5H)-ONE VIA PALLADIUM-CATALYZED CYCLIZATION OF N-(2-BROMOPHENYL)-1H-IMIDAZOLE-4-CARBOXAMIDE

被引：47
|
作者：
KURODA, T [1 ]
SUZUKI, F [1 ]
机构：
[1] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,1188 SHIMOTOGARI,NAGAIZUM CHO,SHIZUOKA 411,JAPAN
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 47期
关键词：
D O I：
10.1016/0040-4039(91)80443-A
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new heterocycle, 5-butyl-1-methyl-1H-imidazo[4,5-c]quinolin-4(5H)-one has been synthesized using palladium-catalyzed cyclization. A yield of the cyclization was optimized by changing base, additive and reaction temperature.
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页码：6915 / 6918
页数：4
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