ENHANCED ARRHYTHMOGENICITY OF FREON-113 BY HYPOXIA IN THE PERFUSED RAT-HEART

被引：1
|
作者：
KAWAKAMI, T
TAKANO, T
ARAKI, R
机构：
[1] TOKYO MED & DENT UNIV,FAC MED,DEPT PUBL HLTH & ENVIRONM SCI,1-5-45 YUSHIMA,TOKYO 113,JAPAN
[2] SAITAMA MED SCH,MOROYAMA,SAITAMA 35004,JAPAN
来源：
TOXICOLOGY AND INDUSTRIAL HEALTH | 1990年 / 6卷 / 3-4期
关键词：
D O I：
10.1177/074823379000600310
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The interaction of Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) and hypoxia on the heart conduction system was studied using electrocardiogram monitoring of isolated perfused rat hearts. Freon 113 (0.2 mM) alone elicited significant atrioventricular conduction delay (p < 0.05) and heart rate decrease (p < 0.01), which were significantly enhanced by hypoxia (75% oxygen decrease), for instance, resulting in 2:1 AV block. The data suggest that arrhythmogenicity of Freon 113 on the heart conduction system may be enhanced synergistically by hypoxia.
引用
收藏
页码：493 / 498
页数：6
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