PAEONIFLORIN ATTENUATES LEARNING IMPAIRMENT OF AGED RATS IN OPERANT BRIGHTNESS-DISCRIMINATION TASK

被引：53
|
作者：
OHTA, H
MATSUMOTO, K
SHIMIZU, M
WATANABE, H
机构：
[1] TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DIV PHARMACOL,TOYAMA 93001,JAPAN
[2] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,DEPT MED RESOURCES,PHARMACOGNOCY LAB,TOYAMA,JAPAN
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 49卷 / 01期
关键词：
DISCRIMINATION LEARNING; PAEONIFLORIN; TACRINE; AGING;
D O I：
10.1016/0091-3057(94)90478-2
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The effects of paeoniflorin isolated from peony were examined on an aging-induced learning deficit in an operant brightness discrimination task in Fischer 344 rats. Learning in aged (25 months) rats was significantly impaired compared with young (5 months) rats. Daily administration of paeoniflorin (0.01 mg/kg, PO) significantly attenuated the learning impairment in aged rats, whereas it did not affect the learning in young rats. Although tacrine (0.3 and 1 mg/kg, IP), a cholinesterase inhibitor, also did not affect the learning in young rats, it slightly augmented the aging-induced learning deficit in the present task. These data indicate the therapeutic potential of paeoniflorin in the treatment of senile dementia and aging-induced cognitive dysfunction.
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页码：213 / 217
页数：5
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