METASTATIC EPITHELIOID SARCOMA WITH AN N-RAS ONCOGENE MUTATION

被引：10

作者：

KUSAKABE, H ^{[1
]}

YONEBAYASHI, K ^{[1
]}

SAKATANI, S ^{[1
]}

IKI, M ^{[1
]}

NAKASUJI, K ^{[1
]}

KIYOKANE, K ^{[1
]}

YASUHARA, M ^{[1
]}

NAKAGAWA, J ^{[1
]}

MORI, H ^{[1
]}

机构：

[1] OSAKA MED COLL,DEPT PATHOL 2,TAKATSUKI,OSAKA 569,JAPAN

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 1994年 / 16卷 / 03期

关键词：

EPITHELIOID SARCOMA; METASTASIS; N-RAS ONCOGENE; MUTATION;

D O I：

10.1097/00000372-199406000-00012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

At age 25 a Japanese woman noticed an elastic-hard nodule 2 cm in diameter on the anterior side of her right leg. The nodule had developed an ulcer in its center. Simple resection was performed several times. However, the lesion recurred repeatedly. The patient underwent amputation of the right leg at the age of 34, because the diagnosis of epithelioid sarcoma was established histologically. No recurrence was observed for 9 years. Recently, the patient noticed multiple painful, ulcerative nodules about 1 cm in diameter on her scalp, trunk, and extremities. She refused extensive resection for a religious reason and died of massive hematemesis. Autopsy revealed metastatic epithelioid sarcoma in the skin, lungs, kidneys, pancreas, transverse colon, thyroid, and sternum. Chromosomal analysis of the tumor revealed various aberrations and an N-ras oncogene mutation.

引用

页码：294 / 300

页数：7

共 50 条

[41] POINT MUTATIONS IN THE N-RAS ONCOGENE IN MALIGNANT-MELANOMA AND CONGENITAL NEVI
CARR, J
MACKIE, RM
BRITISH JOURNAL OF DERMATOLOGY, 1994, 131 (01) : 72 - 77
[42] A HIGH-FREQUENCY OF N-RAS ONCOGENE MUTATIONS IN MULTIPLE-MYELOMA
TANAKA, K
TAKECHI, M
ASAOKU, H
DOHY, H
KAMADA, N
INTERNATIONAL JOURNAL OF HEMATOLOGY, 1992, 56 (02) : 119 - 127
[43] N-RAS ONCOGENE ACTIVATION IN A PATIENT WITH GAMMA-HEAVY CHAIN DISEASE
MOSKOVITS, T
JACOBSON, DR
BUXBAUM, J
AMERICAN JOURNAL OF HEMATOLOGY, 1992, 41 (04) : 302 - 303
[44] N-RAS AND KI-RAS MUTATION IN MYELODYSPLASTIC SYNDROMES WITH MONOCYTOSIS AND POOR PROGNOSIS
YUNIS, JJ
BOS, JL
MOLECULAR DIAGNOSTICS OF HUMAN CANCER, 1989, 7 : 147 - 149
[45] PERSISTENCE OF AN ACTIVATING N-RAS ONCOGENE MUTATION IN CLONOGENIC PROGENITOR CELLS FROM AN ACUTE MYELOID-LEUKEMIA PATIENT IN REMISSION
ZAHEER, HA
BAGNARA, M
GIBSON, FM
ROBINSON, G
RUTHERFORD, TR
GORDONSMITH, EC
BRITISH JOURNAL OF HAEMATOLOGY, 1994, 86 (02) : 298 - 302
[46] A novel N-ras mutation in malignant melanoma is associated with excellent prognosis
Demunter, A
Ahmadian, MR
Libbrecht, L
Stas, M
Baens, M
Scheffzek, K
Degreef, H
De Wolf-Peeters, C
van den Oord, JJ
CANCER RESEARCH, 2001, 61 (12) : 4916 - 4922
[47] N-Ras mutation in vemurafenib-associated expanding melanocytic nevus
Harada, Kazutoshi
Kato, Yuichiro
Maeda, Tatsuo
Yoshida, Maki
Irisawa, Ryokichi
Nagao, Toshitaka
Tsuboi, Ryoji
JOURNAL OF DERMATOLOGY, 2017, 44 (05): : e101 - e102
[48] IN-VIVO AND IN-VITRO ANALYSIS OF RETROVIRAL VECTORS CARRYING THE N-RAS ONCOGENE
MATESANZ, F
PELLICER, A
INTERNATIONAL JOURNAL OF ONCOLOGY, 1995, 7 (03) : 443 - 451
[49] MODULATION OF THE TRANSCRIPTION FACTOR AP-2 BY N-RAS ONCOGENE AND RETINOIC ACID
KANNAN, P
BUETTNER, R
CHIAO, PJ
TAINSKY, MA
JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 161 - 161
[50] ACTIVATION MECHANISM OF THE N-RAS ONCOGENE IN HUMAN LEUKEMIAS DETECTED BY SYNTHETIC OLIGONUCLEOTIDE PROBES
NISHIDA, J
HIRAI, H
TAKAKU, F
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (02) : 870 - 875

← 1 2 3 4 5 →