METASTATIC EPITHELIOID SARCOMA WITH AN N-RAS ONCOGENE MUTATION

被引：10

作者：

KUSAKABE, H ^{[1
]}

YONEBAYASHI, K ^{[1
]}

SAKATANI, S ^{[1
]}

IKI, M ^{[1
]}

NAKASUJI, K ^{[1
]}

KIYOKANE, K ^{[1
]}

YASUHARA, M ^{[1
]}

NAKAGAWA, J ^{[1
]}

MORI, H ^{[1
]}

机构：

[1] OSAKA MED COLL,DEPT PATHOL 2,TAKATSUKI,OSAKA 569,JAPAN

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 1994年 / 16卷 / 03期

关键词：

EPITHELIOID SARCOMA; METASTASIS; N-RAS ONCOGENE; MUTATION;

D O I：

10.1097/00000372-199406000-00012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

At age 25 a Japanese woman noticed an elastic-hard nodule 2 cm in diameter on the anterior side of her right leg. The nodule had developed an ulcer in its center. Simple resection was performed several times. However, the lesion recurred repeatedly. The patient underwent amputation of the right leg at the age of 34, because the diagnosis of epithelioid sarcoma was established histologically. No recurrence was observed for 9 years. Recently, the patient noticed multiple painful, ulcerative nodules about 1 cm in diameter on her scalp, trunk, and extremities. She refused extensive resection for a religious reason and died of massive hematemesis. Autopsy revealed metastatic epithelioid sarcoma in the skin, lungs, kidneys, pancreas, transverse colon, thyroid, and sternum. Chromosomal analysis of the tumor revealed various aberrations and an N-ras oncogene mutation.

引用

页码：294 / 300

页数：7

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