EFFECT OF TMB-8 ON ALPHA-ADRENOCEPTOR AGONIST AND KCL INDUCED-CONTRACTIONS IN ISOLATED RABBIT AORTA

被引：7
|
作者：
ALEIXANDRE, MA
KING, AP
PUERRO, M
机构：
[1] Departamento de Farmacología, Facultad de Medicina, Universidad Complutense
来源：
GENERAL PHARMACOLOGY | 1993年 / 24卷 / 04期
关键词：
D O I：
10.1016/0306-3623(93)90170-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. TMB-8 (10(-6) M-10(-4) M) depresses the contractile effect of the selective alpha1-adrenoceptor agonists methoxamine and phenylephrine in the isolated rabbit aorta. 2. TMB-8 also depresses contractions evoked by 80 mM KCl in this tissue when used at similar concentrations. 3. The calcium antagonist nifedipine potentiates the inhibitory effect of TMB-8 on the alpha1-contractions. 4. In preparations mounted in Ca-free solution containing 0.5 mM EGTA, 10(-4) M TMB-8 markedly depressed the contractions caused by both alpha1-adrenoceptor agonists. 5. The Ca2+ agonist BAY K 8644 (10(-6) M) partially prevented the inhibitory effect of TMB-8 on 80 mM KCl contractions.
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页码：921 / 928
页数：8
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