8-OH-DPAT ATTENUATES THE DEXFENFLURAMINE-INDUCED INCREASE IN EXTRACELLULAR SEROTONIN - AN IN-VIVO DIALYSIS STUDY

被引：12
|
作者：
GARDIER, AM
TRILLAT, AC
MALAGIE, I
JACQUOT, C
机构：
[1] Faculté de Pharmacie, Laboratoire de Pharmacologie JE 92-372, F-92296 Chatenay-Malabry Cedex, Tour D1
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 265卷 / 1-2期
关键词：
DEXFENFLURAMINE; 8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); 5-HT1A AUTORECEPTOR; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); RELEASE; FRONTAL CORTEX; MICRODIALYSIS;
D O I：
10.1016/0014-2999(94)90231-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Rats with frontocortical microdialysis probes were treated with dexfenfluramine or dexfenfluramine with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) pretreatement. Dexfenfluramine (10 mg/kg i.p.) increased extracellular serotonin (5-hydroxytryptamine, 5-HT) (calculated area under the curve (AUC) for the 0 to 105-min period after dexfenfluramine treatment = 8.22 +/- 2.66 pmol 5-HT). Systemic (0.025 mg/kg i.p.) or local (0.01 mu M into the dorsal raphe nucleus) 8-OH-DPAT pretreatement decreased the dexfenfluramine response (AUC: 1.03 +/- 0.07 and 0.44 +/- 0.04 pmol 5-HT, respectively). This result might be explained by the decrease in 5-HT neuronal discharge caused by somatodendritic 5-HT1A autoreceptor activation, and suggests that the 5-HT releasing effect of dexfenfluramine in vivo depends on nerve terminal depolarization.
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页码：107 / 110
页数：4
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