The case history, diagnosis and management of 2 pts with villous adenoma of the duodenum are reported. Both were operated on with good results, with no relapse at 12 and 18 months of observation. This tumor which is more frequently located in the vicinity of the Vater Ampullae, has a low incidence. One third of them have malignant elements raising an issue on therapeutic options. Literature is reviewed with special emphasis on the type of surgical resection to be used.