EFFECTS OF 32-OXYGENATED LANOSTEROL DERIVATIVES ON 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY AND CHOLESTEROL-BIOSYNTHESIS FROM 24,25-DIHYDROLANOSTEROL

被引：9
|
作者：
SONODA, Y
OBI, N
ONODA, M
SAKAKIBARA, Y
SATO, Y
机构：
[1] Kyoritsu College of Pharmacy, Tokyo 105, Shibakoen 1-chome, Minato-ku
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 10期
关键词：
3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE; CHOLESTEROL BIOSYNTHESIS; LANOSTEROL DEMETHYLATION; 32-OXYGENATED LANOSTEROL DERIVATIVE; 24,25-DIHYDROLANOSTEROL;
D O I：
10.1248/cpb.40.2796
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and cholesterol biosynthesis from [24,25-H-3]24,25-dihydrolanosterol were studied. Among the derivatives, 3beta-hydroxylanost-7-en-32-oic acid was the most active in depressing HMG-CoA reductase activity (IC50: 0.7 muM) and cholesterol biosynthesis (IC50: 0.4 muM) from 24,25-dihydrolanosterol.
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页码：2796 / 2799
页数：4
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