SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL SPIRO 4-THIAZOLINONE DERIVATIVES AS ANTIMICROBIAL AGENTS

被引：0

作者：

Shah, Purvesh J. ^{[1
]}

Patel, Paresh N. ^{[2
]}

Patel, Khyati D. ^{[2
]}

Patel, Hasmukh S. ^{[2
]}

机构：

[1] KK Shah Jarodawala Maninagar Sci Coll, Dept Chem, Maninagar 380008, Gujarat, India

[2] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

HETEROCYCLIC LETTERS | 2014年 / 4卷 / 04期

关键词：

Spiro; 4-thiazolidinone; thiazolopyrimidine; pyrazolothiazole; thiazolopyridine; bis-thiazolopyrimidine; antimicrobial activities;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the present communication, novel spiro 4-thiazolinone derivatives were synthesized by superficial and swift method. The newly synthesized compounds were characterized by IR, NMR, MS and elemental analyses. All newly synthesized compounds were screened for their antibacterial (Staphylococcus aureus, Streptococcus viridans and Escherichia coil) and antifungal (Gibberela, Cercospora arachidicola, Physolospora piricola and Fusarium oxysporum) studies. Their results revealed that the present work provided a novel class of spiro-based 4-thiazolinone derivatives with potent microbial activities for further optimization against the tested microorganisms.

引用

页码：537 / 547

页数：11

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