IDENTIFICATION AND CHARACTERIZATION OF THE VIRION-INDUCED HOST SHUTOFF PRODUCT OF HERPES-SIMPLEX VIRUS GENE UL41

被引：93

作者：

SMIBERT, CA ^{[1
]}

JOHNSON, DC ^{[1
]}

SMILEY, JR ^{[1
]}

机构：

[1] MCMASTER UNIV,MOLEC VIROL & IMMUNOL PROGRAM,HAMILTON L8N 3Z5,ONTARIO,CANADA

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-2-467

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

引用

页码：467 / 470

页数：4

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