IDENTIFICATION AND CHARACTERIZATION OF THE VIRION-INDUCED HOST SHUTOFF PRODUCT OF HERPES-SIMPLEX VIRUS GENE UL41

被引：93
|
作者：
SMIBERT, CA [1 ]
JOHNSON, DC [1 ]
SMILEY, JR [1 ]
机构：
[1] MCMASTER UNIV,MOLEC VIROL & IMMUNOL PROGRAM,HAMILTON L8N 3Z5,ONTARIO,CANADA
来源：
JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷
关键词：
D O I：
10.1099/0022-1317-73-2-467
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.
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页码：467 / 470
页数：4
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