THE EVALUATION OF 2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSLY NUCLEOSIDES AS POTENTIAL ANTISENSE CONSTRUCTS - SYNTHESIS, BIOPHYSICAL PROPERTIES AND ENZYMATIC STABILITY OF 2'-DEOXYADENOSINE-(3'-6')-[1-(2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSYL)THYMINE] PHOSPHATE

被引：1

作者：

TARI, LW ^{[1
]}

SADANA, KL ^{[1
]}

SECCO, AS ^{[1
]}

机构：

[1] UNIV MANITOBA,DEPT CHEM,WINNIPEG,MB R3T 2N2,CANADA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1080/15257779508014661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1-(2',3'-dideoxy-beta-D-erythro-hex-2'-enopryanosyl)thymine was used as a nucleoside substitute in the synthesis of the dimer ApT*. CD studies on the dimer show that it adopts stacked, B-form mini-helices in solution. The title compound, relative to natural ApT, possesses an increased resistance to degradation by nucleases.

引用

页码：175 / 183

页数：9

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