THE EVALUATION OF 2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSLY NUCLEOSIDES AS POTENTIAL ANTISENSE CONSTRUCTS - SYNTHESIS, BIOPHYSICAL PROPERTIES AND ENZYMATIC STABILITY OF 2'-DEOXYADENOSINE-(3'-6')-[1-(2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSYL)THYMINE] PHOSPHATE

被引：1
|
作者：
TARI, LW [1 ]
SADANA, KL [1 ]
SECCO, AS [1 ]
机构：
[1] UNIV MANITOBA,DEPT CHEM,WINNIPEG,MB R3T 2N2,CANADA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 1-2期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1080/15257779508014661
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1-(2',3'-dideoxy-beta-D-erythro-hex-2'-enopryanosyl)thymine was used as a nucleoside substitute in the synthesis of the dimer ApT*. CD studies on the dimer show that it adopts stacked, B-form mini-helices in solution. The title compound, relative to natural ApT, possesses an increased resistance to degradation by nucleases.
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页码：175 / 183
页数：9
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