STIMULATION OF MEDIAN, BUT NOT DORSAL, RAPHE 5-HT1A AUTORECEPTORS BY THE LOCAL APPLICATION OF 8-OH-DPAT REVERSES RACLOPRIDE-INDUCED CATALEPSY IN THE RAT

被引：28
|
作者：
WADENBERG, ML
HILLEGAART, V
机构：
[1] ASTRA ARCUS AB,DEPT BEHAV PHARMACOL,SODERTALJE,SWEDEN
[2] UNIV STOCKHOLM,DEPT PSYCHOL,S-10691 STOCKHOLM,SWEDEN
来源：
NEUROPHARMACOLOGY | 1995年 / 34卷 / 05期
关键词：
CATALEPSY; RAPHE; SEROTONIN; DOPAMINE; 5-HT1A RECEPTOR; DOPAMINE D-2 RECEPTOR;
D O I：
10.1016/0028-3908(95)00013-V
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The local application of 8-OH-DPAT (0.5 or 2.5 mu g/rat, 10 min) into the median, but not the dorsal, raphe nucleus resulted in a reversal of the catalepsy induced by the DA D-2 receptor blocking agent raclopride (16mg kg(-1) s.c., 60 min). The local application of 8-OH-DPAT into serotonergic projection areas of the forebrain (dorso-lateral neostriatum, accumbens core; 0.5 or 2.0 mu g/side) did not affect raclopride-induced catalepsy. Thus, the 5-HT1A autoreceptor in the median raphe nucleus is an important site of action for the reversal of DA D-2 receptor antagonist-induced catalepsy by systemic administration of 5-HT1A receptor agonists, in the rat.
引用
收藏
页码：495 / 499
页数：5
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