Control of neuronal migration through rostral migratory stream in mice

被引:38
|
作者
Sun, Woong [1 ,2 ]
Kim, Hyun [1 ,2 ]
Moon, Younghye [1 ,2 ,3 ]
机构
[1] Korea Univ, Coll Med, Dept Anat, Seoul, South Korea
[2] Korea Univ, Coll Med, Div Brain Korea Biomed Sci 21, Seoul, South Korea
[3] Seoul Natl Univ, Coll Nat Sci, Sch Biol Sci, Brain & Neuroendocrine Lab, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
Neuronal migration; Rostral migratory stream; Neuroblasts; Adult neurogenesis;
D O I
10.5115/acb.2010.43.4.269
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.
引用
收藏
页码:269 / 279
页数:11
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