MOLECULAR ANALYSIS OF THE ROLE OF THE HLA CLASS-II GENES DRB1, DQA1, DQB1, AND DPB1 IN SUSCEPTIBILITY TO LYME ARTHRITIS

被引：22
|
作者：
RUBERTI, G
BEGOVICH, AB
STEERE, AC
KLITZ, W
ERLICH, HA
FATHMAN, CG
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV IMMUNOL & RHEUMATOL,S021,STANFORD,CA 94305
[2] CETUS CORP,DEPT HUMAN GENET,EMERYVILLE,CA 94608
[3] UNIV CALIF BERKELEY,DEPT INTEGRAT BIOL,BERKELEY,CA 94720
[4] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DEPT MED,DIV IMMUNOL & RHEUMATOL,BOSTON,MA 02111
来源：
HUMAN IMMUNOLOGY | 1991年 / 31卷 / 01期
关键词：
D O I：
10.1016/0198-8859(91)90044-A
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Using the polymerase chain reaction and sequence-specific oligonucleotide probes, we have determined the distribution of the alleles at the polymorphic class II loci, DRB1, DQA1, DQB1, and DPB1 in 25 patients with Lyme arthritis. Comparison of the frequencies of the DRB1 and DPB1 alleles in Lyme arthritis patients to the Centre d'Etude du Polymorphisme Humaine control panel revealed statistically significant differences between the two groups. An increase in DRB1*1301 is noted along with a unique distribution of the DR4 subtypes within the 9 DR4+ patients. In addition, an increase in the rate DPB1*1001 and the more common DPB1*0201 alleles is reported.
引用
收藏
页码：20 / 27
页数：8
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