PYRIMIDINE-DERIVATIVES .9. SYNTHESIS OF BROMO-SUBSTITUTED 5-NITRO-2,4(1H,3H)-PYRIMIDINEDIONE DERIVATIVES

被引：1
|
作者：
KINOSHITA, T
WATANABE, Y
NAKAO, S
FURUKAWA, S
机构：
[1] School of Pharmaceutical Sciences, Nagasaki University, Nagasaki, 852
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 07期
关键词：
D O I：
10.1002/jhet.5570290719
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The following 5-nitro-2,4(1H,3H)pyrimidinediones possessing bromo substituted side chains at the 1- and 6-positions were prepared by bromination of 3,6-dimethyl-1-(omega-hydroxyalkyl)-5-nitro-2,4(1H,3H)-pyrimidinediones 4a and 4b and its nitrates 2a and 2b. The three of mono-bromo derivatives are: 1-(omega-acetoxyalkyl and omega-hydroxyalkyl)-6-bromomethyl-3-methyl- 6a, 6b, 7a and 7b and 1-(omega-bromoalkyl)-3,6-dimethyl-2,4(1H,3H)-pyrimidinediones 8a and 8b. The one type dibromo derivatives are: 1-(omega-bromoalkyl)-6-bromomethyl-3-methyl-2,4(1H,3H)-pyrimidinediones 5a and 5b.
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页码：1785 / 1788
页数：4
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