NEUTROPHIL PRIMING BY HEPATOCYTE GROWTH-FACTOR, A NOVEL CYTOKINE

被引：0

作者：

JIANG, W ^{[1
]}

PUNTIS, MCA ^{[1
]}

NAKAMURA, T ^{[1
]}

HALLETT, MB ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

IMMUNOLOGY | 1992年 / 77卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.

引用

页码：147 / 149

页数：3

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