NEUTROPHIL PRIMING BY HEPATOCYTE GROWTH-FACTOR, A NOVEL CYTOKINE

被引：0
|
作者：
JIANG, W [1 ]
PUNTIS, MCA [1 ]
NAKAMURA, T [1 ]
HALLETT, MB [1 ]
机构：
[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN
来源：
IMMUNOLOGY | 1992年 / 77卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.
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页码：147 / 149
页数：3
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