DETERMINATION OF DILTIAZEM HYDROCHLORIDE ENANTIOMERS IN DOG PLASMA USING CHIRAL STATIONARY-PHASE LIQUID-CHROMATOGRAPHY

被引：9
|
作者：
ISHII, K
BANNO, K
MIYAMOTO, T
KAKIMOTO, T
机构：
[1] Analytical Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., Yodogawa-ku, Osaka, 16-89
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 01期
关键词：
D O I：
10.1016/0378-4347(91)80100-Q
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The separation and determination of d- and l-diltiazem hydrochloride in dog plasma by a two-column high-performance liquid chromatographic technique are described. Diltiazem hydrochloride and its metabolites were extracted from dog plasma and analyzed on a conventional column (Nucleosil 5C18) with a volatile buffer system. The column effluent of diltiazem hydrochloride was collected and evaporated. The enantiomeric ratio of the collected diltiazem was determined using a chiral column (Chiralcel OC). The method was accurate and sensitive.
引用
收藏
页码：338 / 345
页数：8
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