DETERMINATION OF DILTIAZEM HYDROCHLORIDE ENANTIOMERS IN DOG PLASMA USING CHIRAL STATIONARY-PHASE LIQUID-CHROMATOGRAPHY

被引：9
|
作者：
ISHII, K
BANNO, K
MIYAMOTO, T
KAKIMOTO, T
机构：
[1] Analytical Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., Yodogawa-ku, Osaka, 16-89
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 01期
关键词：
D O I：
10.1016/0378-4347(91)80100-Q
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The separation and determination of d- and l-diltiazem hydrochloride in dog plasma by a two-column high-performance liquid chromatographic technique are described. Diltiazem hydrochloride and its metabolites were extracted from dog plasma and analyzed on a conventional column (Nucleosil 5C18) with a volatile buffer system. The column effluent of diltiazem hydrochloride was collected and evaporated. The enantiomeric ratio of the collected diltiazem was determined using a chiral column (Chiralcel OC). The method was accurate and sensitive.
引用
收藏
页码：338 / 345
页数：8
相关论文
共 50 条
  • [1] DETERMINATION OF PROPRANOLOL ENANTIOMERS IN HUMAN-PLASMA AND URINE AND IN RAT-TISSUES USING CHIRAL STATIONARY-PHASE LIQUID-CHROMATOGRAPHY
    TAKAHASHI, H
    KANNO, S
    OGATA, H
    KASHIWADA, K
    OHIRA, M
    SOMEYA, K
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (11) : 993 - 995
  • [2] DETERMINATION OF KETOROLAC ENANTIOMERS IN PLASMA USING ENANTIOSELECTIVE LIQUID-CHROMATOGRAPHY ON AN ALPHA(1)-ACID GLYCOPROTEIN CHIRAL STATIONARY-PHASE AND ULTRAVIOLET DETECTION
    MILLS, MH
    MATHER, LE
    GU, XS
    HUANG, JL
    [J]. JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 658 (01): : 177 - 182
  • [3] THE DIRECT DETERMINATION OF THE ENANTIOMERS OF KETOROLAC AND PARAHYDROXYKETOROLAC IN PLASMA AND URINE USING ENANTIOSELECTIVE LIQUID-CHROMATOGRAPHY ON A HUMAN SERUM ALBUMIN-BASED CHIRAL STATIONARY-PHASE
    DIAZPEREZ, MJ
    CHEN, JC
    AUBRY, AF
    WAINER, IW
    [J]. CHIRALITY, 1994, 6 (04) : 283 - 289
  • [4] DETERMINATION OF THE ENANTIOMERS OF NISOLDIPINE IN HUMAN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON A CHIRAL STATIONARY-PHASE AND GAS-CHROMATOGRAPHY WITH MASS-SELECTIVE DETECTION
    HEINIG, R
    MUSCHALEK, V
    AHR, G
    [J]. JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 655 (02): : 286 - 292
  • [5] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF DIAMINE ENANTIOMERS AS SCHIFF-BASES ON A CHIRAL STATIONARY-PHASE
    DUCHATEAU, ALL
    GUNS, JJ
    KUBBEN, RGR
    VANTILBURG, AFP
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1994, 664 (02) : 169 - 176
  • [6] BUCKMINSTERFULLERENE AS A STATIONARY-PHASE IN LIQUID-CHROMATOGRAPHY
    JINNO, K
    FUKUOKA, K
    FETZER, JC
    BIGGS, WR
    [J]. JOURNAL OF MICROCOLUMN SEPARATIONS, 1993, 5 (06) : 517 - 523
  • [7] DETERMINATION OF FELODIPINE ENANTIOMERS USING CHIRAL STATIONARY PHASE LIQUID-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY, AND THE STUDY OF THEIR PHARMACOKINETIC PROFILES IN HUMAN AND DOG
    SAKAMOTO, T
    OHTAKE, Y
    ITOH, M
    TABATA, S
    KURIKI, T
    UNO, K
    [J]. BIOMEDICAL CHROMATOGRAPHY, 1993, 7 (02) : 99 - 103
  • [8] ENANTIOMERS SEPARATION BY LIQUID-CHROMATOGRAPHY ON CHIRAL STATIONARY PHASES
    LIENNE, M
    CAUDE, M
    TAMBUTE, A
    ROSSET, R
    [J]. ANALUSIS, 1987, 15 (09) : 431 - 476
  • [9] STUDIES ON SEPARATION OF DERIVATIVES OF AMINO-ACID OF ENANTIOMERS ON CHIRAL STATIONARY-PHASE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SHEN, HX
    YANG, GS
    GAO, RY
    WANG, QS
    [J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1995, 16 (07): : 1072 - 1074
  • [10] RESOLUTION OF EPOXIDE ENANTIOMERS OF POLYCYCLIC AROMATIC-HYDROCARBONS BY CHIRAL STATIONARY-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    WEEMS, HB
    MUSHTAQ, M
    YANG, SK
    [J]. ANALYTICAL BIOCHEMISTRY, 1985, 148 (02) : 328 - 338
12345