NON-STEROL STRUCTURAL PROBES OF THE LANOSTEROL 14-ALPHA-DEMETHYLASE FROM SACCHAROMYCES-CEREVISIAE

被引：7
|
作者：
WRIGHT, GD [1 ]
PARENT, T [1 ]
HONEK, JF [1 ]
机构：
[1] UNIV WATERLOO,GUELPH WATERLOO CTR GRAD WORK CHEM,DEPT CHEM,WATERLOO N2L 3G1,ONTARIO,CANADA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1040卷 / 01期
关键词：
(S. cerevisiae); Lanosterol demethylase; Non-sterol probe;
D O I：
10.1016/0167-4838(90)90151-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of non-sterol iron-liganding molecules were used to probe the active site of the lanosterol 14α-demethylase from Saccharomyces cerevisiae. Simple bi- and tricyclic aromatic amines were found to exhibit Type II binding spectra with the demethylase. Stereochemical and positional effects appear to play critical roles in the binding of these compounds to the demethylase. These compounds have been used to generate additional active-site structural information on this enzyme, currently a target for the development of new antifungal agents. © 1990.
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页码：95 / 101
页数：7
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