FURTHER EVIDENCE SUPPORTING THE IMPORTANCE OF AND THE RESTRICTIONS ON A CARBON-CENTERED RADICAL FOR HIGH ANTIMALARIAL ACTIVITY OF 1,2,4-TRIOXANES LIKE ARTEMISININ

被引：117
|
作者：
POSNER, GH [1 ]
WANG, DS [1 ]
CUMMING, JN [1 ]
OH, CH [1 ]
FRENCH, AN [1 ]
BODLEY, AL [1 ]
SHAPIRO, TA [1 ]
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 13期
关键词：
D O I：
10.1021/jm00013a001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2273 / 2275
页数：3
相关论文
共 29 条
  • [21] Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes
    Maurya, Ranjani
    Soni, Awakash
    Anand, Devireddy
    Ravi, Makthala
    Raju, Kanumuri S. R.
    Taneja, Isha
    Naikade, Niraj K.
    Puri, S. K.
    Wahajuddin
    Kanojiya, Sanjeev
    Yadav, Prem P.
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (02): : 165 - 169
  • [22] The structure and antimalarial activity of some 1,2,4-trioxanes, 1,2,4,5-tetroxanes, and bicyclic endoperoxides. Implications for the mode of action
    Jefford, CW
    Rossier, JC
    Milhous, WK
    HETEROCYCLES, 2000, 52 (03) : 1345 - +
  • [23] Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites:: Implications for the molecular mechanism of action of the artemisinins
    O'Neill, PM
    Rawe, SL
    Borstnik, K
    Miller, A
    Ward, SA
    Bray, PG
    Davies, J
    Oh, CH
    Posner, GH
    CHEMBIOCHEM, 2005, 6 (11) : 2048 - 2054
  • [24] Novel saturated 1,2,4-trioxanes and their antimalarial activity against multidrug resistant Plasmodium yoelii nigeriensis in Swiss mice model via oral route
    Kumari, Akriti
    Yadav, Priyanka
    Rawat, Varun
    Maurya, Ram Avatar
    Islam, Mohammad Shahidul
    Eldesoky, Gaber E.
    Puri, Sunil K.
    Verma, Ved Prakash
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 108
  • [25] Kinetic parameters for the reaction of 1,2,4-trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
    Lopes, Nicolas S.
    Ciscato, Luiz Francisco M. L.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 91 (01) : 328 - 331
  • [26] Novel amino- and hydroxy-functionalized 1,2,4-trioxanes and their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular and oral route
    Yadav, Priyanka
    Naikade, Niraj Krishna
    Hassam, Mohammad
    Singh, Ajit Shankar
    Singh, Chandan
    Puri, Sunil K.
    Verma, Ved Prakash
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 97
  • [27] Crystal structure of 3-amino-5-methyl-1,2,4-benzotriazine 1-oxide: Evidence for formation of a covalent attachment between a carbon-centered radical and the antitumor agent tirapazamine
    Tarra Fuchs
    Charles L. Barnes
    Kent S. Gates
    Journal of Chemical Crystallography, 2001, 31 : 387 - 391
  • [28] Crystal structure of 3-amino-5-methyl-1,2,4-benzotriazine 1-oxide: Evidence for formation of a covalent attachment between a carbon-centered radical and the antitumor agent tirapazamine
    Fuchs, T
    Barnes, CL
    Gates, KS
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2001, 31 (7-8) : 387 - 391
  • [29] IN-VIVO POTENT ANTIMALARIAL 1,2,4-TRIOXANES - SYNTHESIS AND ACTIVITY OF 8-(ALPHA-ARYLVINYL)6,7,10-TRIOXASPIRO,[4,5]DECANES AND 3-(ALPHA-ARYLVINYL)-1,2,5-TRIOXASPIRO[5,5]UNDECANES AGAINST PLASMODIUM-BERGHEI IN MICE
    SINGH, C
    MISRA, D
    SAXENA, G
    CHANDRA, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (17) : 1913 - 1916
123