INHIBITION OF THE UNCOATING OF BOVINE ENTEROVIRUS BY SHORT CHAIN FATTY-ACIDS

被引：14
|
作者：
ISMAILCASSIM, N
CHEZZI, C
NEWMAN, JFE
机构：
[1] UNIV WITWATERSRAND,NATL INST VIROL,PRIVATE BAG X4,SANDRINGHAM 2131,SOUTH AFRICA
[2] RHODES UNIV,DEPT MICROBIOL,GRAHAMSTOWN 6140,SOUTH AFRICA
来源：
JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷
关键词：
D O I：
10.1099/0022-1317-71-10-2283
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Short chain fatty acids inhibit the replication of bovine enterovirus but are almost ineffective against poliovirus type 1, coxsackievirus B5, encephalomyocarditis virus and human rhinovirus 1B. Lauric acid binds to bovine enterovirus, thereby stabilizing the virus particle to heat degradation. Fatty acid-bound virions attach to susceptible cells but fail to undergo cell-mediated uncoating. The inhibitory effect is reversible with chloroform and may result from a hydrophobic interaction between the fatty acid and a specific site on the virus particle.
引用
收藏
页码：2283 / 2289
页数：7
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