THE KINETICS OF DRUG CLEAVAGE AND RELEASE FROM MATRICES CONTAINING COVALENT POLYMER-DRUG CONJUGATES

被引：18
|
作者：
PITT, CG [1 ]
SCHINDLER, A [1 ]
机构：
[1] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709
来源：
JOURNAL OF CONTROLLED RELEASE | 1995年 / 33卷 / 03期
关键词：
D O I：
10.1016/0168-3659(94)00113-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The kinetic expressions for release of a drug formed by the first-order cleavage of drug-polymer conjugates in a solid polymer film are derived from Fick's second law. It is shown that nearly zero order kinetics can be achieved with certain combinations of the drug diffusion coefficient, the cleavage rate constant and the film dimensions.
引用
收藏
页码：391 / 395
页数：5
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