THE KINETICS OF DRUG CLEAVAGE AND RELEASE FROM MATRICES CONTAINING COVALENT POLYMER-DRUG CONJUGATES

被引：18

作者：

PITT, CG ^{[1
]}

SCHINDLER, A ^{[1
]}

机构：

[1] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF CONTROLLED RELEASE | 1995年 / 33卷 / 03期

关键词：

D O I：

10.1016/0168-3659(94)00113-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The kinetic expressions for release of a drug formed by the first-order cleavage of drug-polymer conjugates in a solid polymer film are derived from Fick's second law. It is shown that nearly zero order kinetics can be achieved with certain combinations of the drug diffusion coefficient, the cleavage rate constant and the film dimensions.

引用

页码：391 / 395

页数：5

共 50 条

[1] The kinetics of drug cleavage and release from matrices containing covalent polymer-drug conjugates (vol 33, pg 391, 1995)
Pitt, CG
Schindler, A
JOURNAL OF CONTROLLED RELEASE, 1996, 39 (01) : 111 - 111
[2] Covalent polymer-drug conjugates
Elvira, C
Gallardo, A
San Roman, J
Cifuentes, A
MOLECULES, 2005, 10 (01) : 114 - 125
[3] Polymer-drug conjugates: Manipulation of drug delivery kinetics
Pitt, CG
Wertheim, J
Wang, CT
Shah, SS
MACROMOLECULAR SYMPOSIA, 1997, 123 : 225 - 234
[4] Interplay between Diffusion and Bond Cleavage Reaction for Determining Release in Polymer-Drug Conjugates
Kalosakas, George
MATERIALS, 2023, 16 (13)
[5] Critical Design Strategies Supporting Optimized Drug Release from Polymer-Drug Conjugates
Dordevic, Snezana
Medel, Maria
Hillaert, Justine
Masia, Esther
Conejos-Sanchez, Inmaculada
Vicent, Maria J.
SMALL, 2024, 20 (04)
[6] Polymer-drug conjugates containing antimalarial drugs and antibiotics
Alven, S.
Aderibigbe, B. A.
Balogun, M. O.
Matshe, W. M. R.
Ray, S. S.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 53
[7] Antiviral polymer-drug conjugates
不详
MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK, 2008, 39 (01) : A5 - A5
[8] Polymer-Drug Conjugates for Anticancer Drug Delivery
Wadhwaa, Saurabh
Mumper, Russell J.
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2015, 32 (03): : 215 - 245
[9] Responsive brush polymer-drug conjugates and polymeric nanocapsules for triggered drug release
Yu, Yun
Chen, Chih-Kuang
Li, Yukun
Law, Wing-Cheung
Wang, Qing
Zou, Jiong
Prasad, Paras N.
Cheng, Chong
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[10] Potentiation of radioresponse by polymer-drug conjugates
Ke, S
Milas, L
Charnsangavej, C
Wallace, S
Li, C
JOURNAL OF CONTROLLED RELEASE, 2001, 74 (1-3) : 237 - 242

← 1 2 3 4 5 →