ABNORMAL ENDOTHELIAL-MEDIATED REGULATION OF VASCULAR TONE IN ARTERIOSCLEROSIS

被引:0
|
作者
MUGGE, A
机构
来源
ZEITSCHRIFT FUR KARDIOLOGIE | 1994年 / 83卷 / 10期
关键词
ENDOTHELIUM-DERIVED RELAXING FACTOR; ARTERIOSCLEROSIS; HYPERCHOLESTEROLEMIA; NO-SYNTHASE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Knowledge regarding the endothelial-derived relaxing factor (EDRF) has substantially increased over recent years. The chemical identification of EDRF as nitric oxide (NO) and the discovery of the NO-pathway started an exciting research field with new insights into the regulation of many biologic processes. Concerning regulation of the vascular tone, EDRF(NO) is one of the most potent relaxant substances known; in addition, EDRF(NO) is a potent inhibitor of platelet adhesion and aggregation and leukocyte adhesion to the vascular wall; furthermore, EDRF(NO) is probably an inhibitor of smooth muscle cell proliferation. This profile of EDRF(NO) may be an important part of the anti-arteriosclerotic function of intact endothelial cells. In animal models of hypercholesterolemia and in patients with hypercholesterolemia and/or arteriosclerosis, the EDRF(NO) mechanism is impaired or almost abolished (= endothelial dysfunction). The reason for this abnormal endothelial function is not fully understood and may be multifactorial; it has been suggested that this endothelial dysfunction is due to an accelerated breakdown of EDRF(NO) by oxidixed low density lipoprotein and/or oxygen derived free radicals. In addition, there may be an increased release of vasoconstrictive substances, e.g., endothelin-1, from endothelial cells which may override the relaxant effects of EDRF (NO). This abnormal function of the endothelium (in terms of the EDRF(NO) mechanism) appears to be reversible in animal models and in patients with hypercholesterolemia, and is accomplished by normalizing plasma cholesterol levels.
引用
收藏
页码:759 / 767
页数:9
相关论文
共 50 条
  • [31] EDRF AND THE REGULATION OF VASCULAR TONE
    GRIFFITH, TM
    HENDERSON, AH
    [J]. INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL, 1989, 8 (04): : 383 - 396
  • [32] The regulation of pulmonary vascular tone
    Wilkins, MR
    Zhao, L
    AlTubuly, R
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 42 (01) : 127 - 131
  • [33] Regulation of vascular tone by adipocytes
    Nele Maenhaut
    Johan Van de Voorde
    [J]. BMC Medicine, 9
  • [34] REGULATION OF PULMONARY VASCULAR TONE
    BARNES, PJ
    LIU, SF
    [J]. PHARMACOLOGICAL REVIEWS, 1995, 47 (01) : 87 - 131
  • [35] Regulation of vascular tone by adipocytes
    Maenhaut, Nele
    Van de Voorde, Johan
    [J]. BMC MEDICINE, 2011, 9
  • [36] Aggressive LDL-lowering, endothelial-mediated arteriolar vasodilatation & capillary permeability in patients with atherosclerotic vascular disease.
    DellOmo, G
    Bandinelli, S
    Penno, G
    Navalesi, R
    Pedrinelli, R
    [J]. HYPERTENSION, 1997, 30 (04) : 106 - 106
  • [37] Endothelial-mediated dilations of rat middle cerebral arteries by ATP and ADP
    You, JP
    Johnson, TD
    Childres, WF
    Bryan, RM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 273 (03): : H1472 - H1477
  • [38] ENDOTHELIAL MODULATION OF PULMONARY VASCULAR TONE
    DINHXUAN, AT
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1992, 5 (06) : 757 - 762
  • [39] ENDOTHELIAL CONTROL OF VASCULAR TONE AND GROWTH
    LUSCHER, TF
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1990, 12 (05) : 897 - 902
  • [40] Endothelial modification of pulmonary vascular tone
    Curzen, NP
    Jourdan, KB
    Mitchell, JA
    [J]. INTENSIVE CARE MEDICINE, 1996, 22 (06) : 596 - 607