ANTEROGRADE TRANSPORT OF HSV-1 AND HSV-2 IN THE VISUAL-SYSTEM

被引：23

作者：

NORGREN, RB

MCLEAN, JH

BUBEL, HC

WANDER, A

BERNSTEIN, DI

LEHMAN, MN

机构：

[1] JAMES N GAMBLE INST MED RES,CINCINNATI,OH 45219

[2] UNIV CINCINNATI,COLL MED,DEPT ANAT & CELL BIOL,CINCINNATI,OH 45267

[3] UNIV CINCINNATI,COLL MED,DEPT MICROBIOL & MOLEC GENET,CINCINNATI,OH 45267

[4] UNIV CINCINNATI,COLL MED,DEPT OPHTHALMOL,CINCINNATI,OH 45267

[5] MEM UNIV NEWFOUNDLAND,DIV BASIC MED SCI,ST JOHNS A1B 3V6,NEWFOUNDLAND,CANADA

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 03期

关键词：

ANTEROGRADE; HERPES SIMPLEX VIRUS (HSV); LATERAL GENICULATE NUCLEUS; SUPERIOR COLLICULUS; SUPRACHIASMATIC NUCLEUS; TRANSNEURONAL; VISUAL SYSTEM;

D O I：

10.1016/0361-9230(92)90038-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain Mclntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.

引用

页码：393 / 399

页数：7

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