THE ROLE OF LIPID-PEROXIDATION IN POSTSTRESSOR AGGRAVATION OF INFLUENZA INFECTION AND ITS IONOL CORRECTION

Activation of lipid peroxidation in the tissues of the lungs, brain and liver which was followed by a compensatory increment in the activity of antioxidative enzymes was demonstrated in experimental mice with isolated or combinatory effect of immobilizing stress or influenza infection. The usage of antioxidative drug, ionol, decreased the levels of lipid peroxidation, alleviated the aggravated course of the infection which occurred after the preliminary immobilization. The authors substantiated the role of activation of lipid peroxidation as a significant link in the disease progression in case of isolated or combinatory effect of stress or infection and considered the prospective ways of chemotherapeutic management of viral infections.