APPLICATION OF THE MAILA TECHNIQUE TO THE STUDY OF HUMAN ANTI-HLA MONOCLONAL-ANTIBODY SPECIFICITY

被引：0
|
作者：
SANCHEZ, B
MELERO, J
GARCIALOZANO, JR
YELAMOS, J
MAGARINO, R
ROBLEDO, MM
DESSI, V
SIERVO, S
NUNEZROLDAN, A
机构：
[1] HOSP UNIV VIRGEN ROCIO,SERV INMUNOL,AVDA MANUEL SIUROT S-N,E-41013 SEVILLE,SPAIN
[2] UNIV GENOA,CATTEDRA IMMUNOL,I-16126 GENOA,ITALY
[3] HOFFMANN LA ROCHE AG,CENT RES UNIT,BASEL,SWITZERLAND
来源：
JOURNAL OF IMMUNOLOGICAL METHODS | 1993年 / 157卷 / 1-2期
关键词：
MONOCLONAL ANTIBODY-SPECIFIC IMMOBILIZATION OF LYMPHOCYTE ANTIGENS; HLA; MONOCLONAL ANTIBODY;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The monoclonal antibody-specific immobilization of lymphocyte antigens (MAILA) assay was developed to detect antibodies present in human alloantisera against antigens of different major histocompatibility complex loci, particularly of class II specificity. The MAILA assay has been used in our laboratory to he determination of the type of HLA molecule recognized by human monoclonal antibodies 91C2 (anti-A2 + 28), 34F11 (anti-DQ1), and 2A2 (anti-DQ1 + 4 + short DQ7), using well characterized monomorphic as well as polymorphic murine monoclonals for the specific immobilization of HLA molecules. Results obtained show that the MAILA assay is also a valuable tool for the determination of specific human MHC locus products recognized by human monoclonal antibodies.
引用
收藏
页码：253 / 258
页数：6
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