THE B-CHAIN, BUT NOT THE A-CHAIN, OF RICINUS-COMMUNIS ACTIVATES HUMAN-COMPLEMENT

被引：1
|
作者：
HETLAND, G
MOLLNES, TE
GARRED, P
机构：
[1] Institute of Immunology and Rheumatology, The National Hospital, Oslo
来源：
CANCER LETTERS | 1993年 / 75卷 / 01期
关键词：
RICIN-A CHAIN; RICIN-B CAIN; C3 ACTIVATION PRODUCTS; TERMINAL SC5B-9 COMPLEMENT COMPLEX;
D O I：
10.1016/0304-3835(93)90208-Q
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Complement activation properties of ricin holotoxin, its A or B chain were assessed in two enzyme immunoassays (EIA). One was specific for C3 activation products and the other detected the terminal SC5b-9 complement complex (TCC) and thus determined activation of the initial and terminal part of the complement pathways, respectively. Ricin and its A and B chains were incubated with normal human serum or EDTA-serum. It was found that ricin B chain activated both the initial and terminal complement pathways in a time- and concentration-dependent fashion, whereas the A chain and the holotoxin did not.
引用
收藏
页码：59 / 63
页数：5
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