INDUCTION OF A MUCOSAL BARRIER TO BOVINE HERPESVIRUS-1 REPLICATION IN CATTLE

被引：52
|
作者：
ISRAEL, BA [1 ]
HERBER, R [1 ]
GAO, Y [1 ]
LETCHWORTH, GJ [1 ]
机构：
[1] UNIV WISCONSIN,DEPT VET SCI,1655 LINDEN DR,MADISON,WI 53706
来源：
VIROLOGY | 1992年 / 188卷 / 01期
关键词：
D O I：
10.1016/0042-6822(92)90755-E
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Current vaccines for human and animal herpesviruses engender an immunity that may ameliorate disease but generally fails to prevent infection, latency, reactivation from latency, or spread through a population. By administering intranasally to cattle bovine herpesvirus type 1 virion envelope proteins combined with the potent mucosal immune system adjuvant, cholera toxin B subunit, we engendered a local antibody response that acted as a barrier to infection of mucosal epithelial cells and thereby prevented viral replication, consequently precluding disease, latency, and spread. © 1992.
引用
收藏
页码：256 / 264
页数：9
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