CLONING AND CHARACTERIZATION OF A RECEPTOR-CLASS PHOSPHOTYROSINE PHOSPHATASE GENE EXPRESSED ON CENTRAL-NERVOUS-SYSTEM AXONS IN DROSOPHILA-MELANOGASTER

被引：49
|
作者：
HARIHARAN, IK
CHUANG, PT
RUBIN, GM
机构：
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期
关键词：
TYROSINE PHOSPHORYLATION; ONCOGENES; EYE DEVELOPMENT;
D O I：
10.1073/pnas.88.24.11266
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have cloned and characterized cDNAs coding for a receptor-class phosphotyrosine phosphatase gene from Drosophila melanogaster. The gene maps to the polytene chromosome bands 99A7-8. The cDNA clones code for a polypeptide of 1301 amino acids with a predicted molecular mass of 145 kDa. The extracellular domain includes two fibronectin-type III-like domains. The cytoplasmic region contains two tandemly repeated phosphotyrosine phosphatase-like domains. Residues shown crucial for catalytic activity are absent in the second domain. This Drosophila receptor-class phosphotyrosine phosphatase polypeptide is expressed on axons of the embryonic central nervous system.
引用
收藏
页码：11266 / 11270
页数：5
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