UNSATURATED ANALOGS OF ACYCLIC NUCLEOSIDE PHOSPHONATES - AN UNUSUAL ARBUZOV REACTION WITH UNACTIVATED TRIPLE BOND

被引：2

作者：

PHADTARE, S ^{[1
]}

ZEMLICKA, J ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT INTERNAL MED, DETROIT, MI 48201 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphonates 6 and 8 were prepared by reaction of the corresponding chloroalkenes 5 and 7 with triethyl phosphite. Dealkylation of 6 and 8, combined with acid hydrolysis in case of 8, gave phosphonic acids 3a and 4b. By contrast, chloroalkyne 9 and triethyl phosphite afforded only 2-amino-6-chloro-N9-ethylpurine (10). The same reaction performed in the presence of tetrabutyl-ammonium iodide led to diphosphonate 11. Compound 4b inhibited the growth of murine leukemia L 1210 in culture (IC50 10-mu-M).

引用

页码：275 / 278

页数：4

共 22 条

[21] Stable Pt(IV) vinylic complexes with unusual regio selectivity formed in the reaction of methylpropiolate triple bond activation
Ananikov, VP
Mitchenko, SA
Beletskaya, IP
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2001, 636 (1-2) : 175 - 181
[22] NOVEL TYPES OF ACYCLIC C-NUCLEOSIDE ANALOGS VIA THE REACTION OF HYDROGEN BROMIDE IN ACETIC-ACID WITH L-THREO-(GLYCEROL-1-YL)PYRAZOLINEDIONES
HAMID, HA
RASHED, N
ELKILANY, Y
ELASHRY, ESH
CARBOHYDRATE RESEARCH, 1992, 224 : 41 - 48

← 1 2 3 →