SOMATIC HYPERMUTATION

被引：248
|
作者：
NEUBERGER, MS
MILSTEIN, C
机构：
[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road
来源：
CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期
关键词：
D O I：
10.1016/0952-7915(95)80010-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic features of the hypermutation, dissociated from the effects of antigenic selection.
引用
收藏
页码：248 / 254
页数：7
相关论文
共 50 条
  • [31] DNA Replication to Aid Somatic Hypermutation
    Xu, Zhenming
    Zan, Hong
    Pal, Zsuzsanna
    Casali, Paolo
    MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION XI: B CELL BIOLOGY, 2007, 596 : 111 - 127
  • [32] Genome-wide somatic hypermutation
    Wang, CL
    Harper, RA
    Wabl, M
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (19) : 7352 - 7356
  • [33] The landscape of somatic hypermutation in gynecologic cancer
    Chapman, J. S.
    Chang, M.
    Asthana, S.
    Chen, L. M.
    Schultz, N.
    Taylor, B.
    GYNECOLOGIC ONCOLOGY, 2015, 137 : 59 - 60
  • [34] DNA repair in antibody somatic hypermutation
    Casali, Paolo
    Pal, Zsuzsanna
    Xu, Zhenming
    Zan, Hong
    TRENDS IN IMMUNOLOGY, 2006, 27 (07) : 313 - 321
  • [35] Immunoglobulin transgenes as targets for somatic hypermutation
    Storb, U
    Peters, A
    Klotz, E
    Kim, N
    Shen, HM
    Hackett, J
    Rogerson, B
    O'Brien, R
    Martin, TE
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 1998, 42 (07): : 977 - 982
  • [36] Directed molecular evolution by somatic hypermutation
    Wang, CL
    Yang, DC
    Wabl, M
    PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (09): : 659 - 664
  • [37] The Chromatin Architecture behind Somatic Hypermutation
    Borchert, G. M.
    Larson, E. D.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2009, 50 (07) : 557 - 557
  • [38] Somatic hypermutation in autoimmune thyroid disease
    McIntosh, R
    Watson, P
    Weetman, A
    IMMUNOLOGICAL REVIEWS, 1998, 162 : 219 - 231
  • [39] BCL-2 negative follicular lymphoma is associated with somatic hypermutation of the IGVH genes and aberrant somatic hypermutation
    Gagyi, E.
    Balogh, Z.
    Bodor, C.
    Timar, B.
    Reiniger, L.
    Deak, L.
    Csomor, J.
    Csernus, B.
    Szepesi, A.
    Matolcsy, A.
    ANNALS OF ONCOLOGY, 2008, 19 : 200 - 200
  • [40] Histone modifications associated with somatic hypermutation
    Odegard, VH
    Kim, ST
    Anderson, SM
    Shlomchik, MJ
    Schatz, DG
    IMMUNITY, 2005, 23 (01) : 101 - 110
12345