SOMATIC HYPERMUTATION

被引：246
|
作者：
NEUBERGER, MS
MILSTEIN, C
机构：
[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road
来源：
CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期
关键词：
D O I：
10.1016/0952-7915(95)80010-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic features of the hypermutation, dissociated from the effects of antigenic selection.
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页码：248 / 254
页数：7
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