ABNORMAL DESOLVATION BEHAVIOR ON SOLVATE OF ETODOLAC SODIUM-SALT

被引：0
|
作者：
ZAWADZKI, J [1 ]
LEE, HK [1 ]
DENEALE, R [1 ]
ENEVER, R [1 ]
机构：
[1] WYETH AYERST RES,PHARM RES & DEV,ROUSES POINT,NY 12979
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 06期
关键词：
D O I：
10.1002/jps.2600800613
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sodium salts of (+/-)- and (+)-etodolac were prepared and characterized: the (+/-)-sodium salt contained 5.26% water and 1.09% acetonitrile, and the (+)-sodium salt contained 1.14% water and 2.02% other volatiles (methanol and acetonitrile). Abnormal hygroscopic behavior of the (+/-)-etodolac sodium salt was observed; that is, it lost weight (5.4%) at 75% RH for 7 days. A possible reason for the abnormal hygroscopic behavior is nucleation phenomenon at the interface; that is, a surface change may occur in the presence of water vapor with nucleation by small crystals of the product.
引用
收藏
页码：559 / 563
页数：5
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