ABNORMAL DESOLVATION BEHAVIOR ON SOLVATE OF ETODOLAC SODIUM-SALT

被引：0

作者：

ZAWADZKI, J ^{[1
]}

LEE, HK ^{[1
]}

DENEALE, R ^{[1
]}

ENEVER, R ^{[1
]}

机构：

[1] WYETH AYERST RES,PHARM RES & DEV,ROUSES POINT,NY 12979

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 06期

关键词：

D O I：

10.1002/jps.2600800613

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sodium salts of (+/-)- and (+)-etodolac were prepared and characterized: the (+/-)-sodium salt contained 5.26% water and 1.09% acetonitrile, and the (+)-sodium salt contained 1.14% water and 2.02% other volatiles (methanol and acetonitrile). Abnormal hygroscopic behavior of the (+/-)-etodolac sodium salt was observed; that is, it lost weight (5.4%) at 75% RH for 7 days. A possible reason for the abnormal hygroscopic behavior is nucleation phenomenon at the interface; that is, a surface change may occur in the presence of water vapor with nucleation by small crystals of the product.

引用

页码：559 / 563

页数：5

共 50 条

[1] PHYSICOCHEMICAL BEHAVIOR OF THE SODIUM-SALT OF CARBOXYMETHYLCELLULOSE IN DYE, SALT AND SURFACTANT ENVIRONMENTS
GUPTA, S
MOULIK, SP
DAS, AR
MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1991, 192 (02): : 447 - 460
[2] STRUCTURE OF CARFECILLIN (SODIUM-SALT)
GANE, PAC
BOLES, MO
BIRD, AE
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1982, 38 (MAR): : 929 - 932
[3] SODIUM-SALT CLEARING FROM AMINES
ZAGIDULLIN, RN
KHIMICHESKAYA PROMYSHLENNOST, 1989, (09): : 681 - 682
[4] KINETICS OF DEHYDRATION OF SODIUM-SALT HYDRATES
SHARMA, SK
JOTSHI, CK
KUMAR, S
THERMOCHIMICA ACTA, 1991, 184 (01) : 9 - 23
[5] STRUCTURE OF THE SODIUM-SALT OF PENICILLANIC ACID
GIBON, V
NORBERG, B
EVRARD, G
DURANT, F
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1988, 44 : 652 - 654
[6] PREPARATION AND PURIFICATION OF MALONALDEHYDE SODIUM-SALT
LACOMBE, A
KERMASHA, S
VANDEVOORT, FR
MILLS, BL
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1990, 38 (02) : 418 - 423
[7] TRITIUM LABELED PROSTACYCLIN SODIUM-SALT
HSI, RSP
STOLLE, WT
MCGRATH, JP
MORTON, DR
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1981, 18 (10): : 1437 - 1447
[8] VISCOSITY OF MOLTEN SODIUM-SALT HYDRATES
SHARMA, SK
JOTSHI, CK
SINGH, A
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1984, 29 (03): : 245 - 246
[9] ANALGESIC PROFILE OF THE SODIUM-SALT OF PEMEDOLAC
CHAU, TT
WALTER, T
KATZ, A
WEICHMAN, BM
DRUG DEVELOPMENT RESEARCH, 1993, 28 (04) : 488 - 495
[10] MESOMORPHIC BEHAVIOR OF DODECYL BENZENE SULFONIC-ACID AND ITS SODIUM-SALT
KRISHNAMURTI, D
SOMASHEKAR, R
MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 1981, 65 (1-2): : 3 - 22

← 1 2 3 4 5 →