Relation of Red Cell Distribution Width with Thromboembolic Risk in Patients Had Non-valvular Atrial Fibrillation

Higher red blood cell distribution width (RDW) anticipates harmful events among patients have cardio-vascular diseases. On other hand, there is imperfect information concerning the association between RDW and thrombo-embolism hazard in the patients with atrial fibrillation. We intended to study the relation between RDW and CHA2DS2-VASc scores which utilized for assessment of thrombo-embolic hazard in patients with non-valvular AF. Our study enrolled 46 patients with AF. We calculated CHA2DS2-VASc score for every patient, and we investigate the laboratory and echocardiographic parameters. Depend on CHA2DS2-VASc scores; we classified the AF patients into two groups (low - intermediate risk and high risk groups). Then, we compared mentioned parameters between the 2 groups, and we assessed the relation between RDW and CHA2DS2-VASc score. Multivariate regression analysis was done to find independent predictors of high CHA2DS2-VASc scores. Patients with elevated CHA2DS2-VASc scores had older age and higher RDW, hs-CRP, creatinine serum level, left atrial diameter and intervetricular septum thickness comparably to low CHA2DS2-VASc score group. Multivariate regression analysis appeared that RDW and hs-CRP were independent predictors for high CHA2DS2-VASc scores. RDW is significantly associated with CHA2DS2-VASc score among patients have AF. Furthermore, RDW considers an independent predictor in CHA2DS2-VASc score.