EVALUATION OF THE INVITRO ANTIPROLIFERATIVE PROPERTIES OF 4 NOVEL ANTHRACYCLINES YM1, 3, 4 AND 6 IN HUMAN LEUKEMIA-CELL LINES

被引：0
|
作者：
JIANG, XR [1 ]
NEWLAND, AC [1 ]
MACEY, MG [1 ]
JENKINS, GC [1 ]
MIKI, T [1 ]
ADACHI, K [1 ]
YAMABE, S [1 ]
机构：
[1] ROYAL LONDON HOSP,DEPT HEMATOL,WHITECHAPEL,LONDON E1 1BB,ENGLAND
来源：
JOURNAL OF CHEMOTHERAPY | 1992年 / 4卷 / 05期
关键词：
ANTITUMOR EFFECTS; NOVEL DOXORUBICIN ANALOGS; LEUKEMIA; DRUG RESISTANCE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The antitumor activity of novel doxorubicin analogues YM1, YM3, YM4 and YM6 was evaluated against drug sensitive U937 monocytic leukemia and CCRF-CEM lymphoid leukemia cell lines, as well as drug resistant CEM/VLB 100 lymphoid multidrug resistant leukemia cell line by a [H-3]thymidine incorporation assay. Different antileukemic activities of these new anthracyclines were observed in our studies. These novel anthracyclines produced a dose- and time-dependent inhibition in all the leukemic cell lines tested, while YM1 and YM3 were more effective than YM4 and YM6 against all the leukemic cell lines. The antitumor activity of all these novel analogues was lower than that of doxorubicin or epidoxorubicin in drug sensitive leukemic cells. The relative resistance values (IC50 of resistant cell line/IC50 of sensitive parental cell line) of YM1, 3, 4 and 6 were 27, 7, 5 and 14 respectively. These were lower than the resistance values for ADM and EDR which were 45 and 40 respectively. YM3 had a similar antileukemic activity against the CEM/VLB100. drug resistant leukemic cell line to ADM or EDR with a lower relative resistance value and a slightly increased IC50 value. Our results suggest that YM3 may be used in high dose for the clinical treatment of leukemias with possible less cardiotoxicity as well as less drug resistance.
引用
收藏
页码：306 / 311
页数：6
相关论文
共 50 条
  • [31] EXPRESSION OF THE CR-1 RECEPTOR ON HUMAN LEUKEMIA-DERIVED CD4(+) T-CELL LINES
    YASKANIN, DD
    WAXMAN, FJ
    CELLULAR IMMUNOLOGY, 1995, 163 (01) : 139 - 147
  • [32] QSAR models of antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazoles in various cancer cell lines
    Joanna Matysiak
    Andrzej Niewiadomy
    Molecular Diversity, 2017, 21 : 211 - 218
  • [33] QSAR models of antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazoles in various cancer cell lines
    Matysiak, Joanna
    Niewiadomy, Andrzej
    MOLECULAR DIVERSITY, 2017, 21 (01) : 211 - 218
  • [34] alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines
    Falcioni, R
    Antonini, A
    Nistico, P
    DiStefano, S
    Crescenzi, M
    Natali, PG
    Sacchi, A
    EXPERIMENTAL CELL RESEARCH, 1997, 236 (01) : 76 - 85
  • [35] A SUBSET OF T-CELL RECEPTORS ASSOCIATED WITH L3T4 MOLECULES MEDIATES C6VL LEUKEMIA-CELL BINDING OF ITS COGNATE RETROVIRUS
    ONEILL, HC
    MCGRATH, MS
    ALLISON, JP
    WEISSMAN, IL
    CELL, 1987, 49 (01) : 143 - 151
  • [36] EFFECTS OF CYCLIC-AMP ON EXPRESSION OF LFA-1, MAC-1, AND VLA-4 AND EOSINOPHILIC DIFFERENTIATION OF A HUMAN LEUKEMIA-CELL LINE, EOL-1
    JUNG, EY
    OHSHIMA, Y
    SHINTAKU, N
    SUMIMOTO, SI
    HEIKE, T
    KATAMURA, K
    MAYUMI, M
    EUROPEAN JOURNAL OF HAEMATOLOGY, 1994, 53 (03) : 156 - 162
  • [37] 1-aryl-4,6-dihydropyrazolo[4,3-d] [1]benzazepin-5(1H)-ones:: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines
    Kohfeld, Simone
    Jones, Peter G.
    Totzke, Frank
    Schaehtele, Christoph
    Kubbutat, Michael H. G.
    Kunick, Conrad
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (11-12) : 1317 - 1324
  • [38] INDUCTION OF ICAM-1 EXPRESSION ON THE EOSINOPHILIC LEUKEMIA-CELL LINE-3 (EOL-3) BY PLATELET-ACTIVATING-FACTOR AND PLATELET FACTOR-4
    SEGUCHI, M
    NAKAJIMA, S
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1995, 74 (03) : 255 - 257
  • [39] Analysis of the activation state of alpha 4 beta 1 integrin in human B cell lines derived from myeloma, leukemia or lymphoma
    GarciaGila, M
    Cabanas, C
    GarciaPardo, A
    FEBS LETTERS, 1997, 418 (03) : 337 - 340
  • [40] Effects of 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone from Syzygium nervosum Seeds on Antiproliferative, DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Cervical Cancer Cell Lines
    Utama, Kraikrit
    Khamto, Nopawit
    Meepowpan, Puttinan
    Aobchey, Paitoon
    Kantapan, Jiraporn
    Sringarm, Korawan
    Roytrakul, Sittiruk
    Sangthong, Padchanee
    MOLECULES, 2022, 27 (04):
12345