TRIPLE-HELIX FORMATION OF OLIGODEOXYNUCLEOTIDES CONTAINING [(3'S,5'R)-2'-DEOXY-3',5'-ETHANO-BETA-D-RIBOFURANOSYL]NUCLEOSIDES (BICYCLO-DEOXYNUCLEOSIDES)

被引：0

作者：

BOLLI, M ^{[1
]}

LEUMANN, C ^{[1
]}

机构：

[1] UNIV BERN,INST ORGAN CHEM,CH-3012 BERN,SWITZERLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 06期

关键词：

BICYCLONUCLEOTIDES; DOUBLE HELIX; DNA; OLIGONUCLEOTIDES; RNA; TRIPLE HELIX;

D O I：

10.1002/anie.199506941

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enhanced preference for complexing to an RNA complement on the Hoogsteen side of the nucleobase is the consequence of the sugar modification in oligonucleotides of bicyclodeoxyguanosine 3. Furthermore, oligonucleotides containing bicyclothymidine 1 and bicyclodeoxycytidine 2 provide evidence of specific differences in the preferred sugar conformation of the nucleosides in the third strand in DNA triple helices. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：694 / 696

页数：3

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