SYNTHESIS, MEMBRANE INSERTION AND GLYCOSYLATION OF THYROGLOBULIN IN A COMPLETELY HETEROLOGOUS SYSTEM

被引：3

作者：

EGGO, MC ^{[1
]}

BURROW, GN ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT MED, TORONTO, ONTARIO, CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)90226-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thyroglobulin was synthesized, inserted into membranes and glycosylated in a completely heterologous, reconstituted system consisting of a protein synthesizing extract, stripped dog pancreas microsomal membranes and calf thyroid RNA. There is now considerable evidence to support the hypothesis that secreted glycoproteins are synthesized on polysomes which become membrane-bound following synthesis of an N-terminal hydrophobic signal sequence. This signal presequence was found on more than 20 nascent proteins destined for secretion, ovalbumin being the only exception.

引用

页码：1069 / 1076

页数：8

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